The main focus of the Lam Lab lies in discovering revolutionary and innovative methods of disease treatment on a nano-scale and molecular scale. Our work is most related to molecular medicine, drug discovery, nanoparticle and drug-delivery techniques in cancer and other diseases. Our research is done through the use of cutting edge technologies and established procedures.
Versatile Nanoparticle-based Drug Delivery Platform
We have developed a novel telodendrimer-based micellar nanoparticle platform for efficient drug delivery. It shows great promise in formulating many existing and new drugs to enhance the drug efficacy and lower the drug side-effect for a number of different diseases. These nanoparticles have been successfully used to treat ovarian cancer, breast cancer, prostate cancer, bladder cancer, multiple myeloma and lymphoma animal models and kill leukemia cancer stem cells. Furthermore, a variety of imaging agents, such as fluorescent dyes and radionuclides could be physically encapsulated or covalently attached to the nanoparticles which allow us to use these nanoparticles as contrast agents for SPECT, PET, MRI, CT and fluorescent imaging.