The Britt lab is investigating structure and function of biologically significant enzymes with redox-active transition metal centers, clusters or organic radicals in their active site. The oxygen-evolving complex of Photosystem II, the enzyme complex responsible for water oxidation in photosynthesis, is the major biological system currently under investigation.Â Research Interests:Â Electron Paramagnetic Resonance (EPR) spectroscopy sudies of the Photosystem II Oxygen Evolving Complex,Â Membrane-organized Chemical Photoredox Systems,Â EPR Spectroscopy of the Cobalt Water Splitting Catalyst,Â Photoreceptor Regulation and Optimization of Energy Harvesting,Â EPR Spectrometer for Energy, Chemistry, and Biochemistry Research.
Revolutionizing medicine and treatment through innovative research in areas likeÂ chemical biology, combinatorial chemistry, high-throughput screening, targeted therapy, nanotherapeutics, molecular imaging, tyrosineÂ kinase inhibition, proteomicsÂ and many other novel techniques.Â Research Interests:Â Reversible crosslinked micellar nanoparticles,Â Targeting nanoparticles,Â Biophysical approaches to study protein-nanoparticle interactions,Â Development of new synthetic and screening techniques in peptide, macrocyclic, glyco- and small-molecule combinatorial chemistry,Â Development of peptide-targeted therapy for cancer,Â Protein tyrosine kinases, biochemistry, diagnostics, imaging agents, and drug development,Â Development and characterization of novel 3-D gel matrix for stem cell culture.
Our research is on the interface of synthetic inorganic chemistry and physical chemistry. Most of our projects involve the preparation and characterization of inorganic nanostructures (nanospheres, nanosheets, and nanowires) and their application to solar energy conversion.Â Research Interests:Â Photocatalytic Conversion of Biomass into Gaseous Fuels,Â Nanowire-Based Chemical Sensors,Â Structure-Property Relationships in Nanoparticle Clusters,Â Plasmon-Enhanced Photovoltaic Cells,Â Nanoparticle-Based Catalysts for Photochemical Water Splitting.
Research in our group is focused on two general areas: 1) development and use of new multicomponent reactions and 2) discovery of chemical inhibitors of bacterial cell division. Both areas involve the development of new synthetic methods, the synthesis of natural products, and the elucidation of interactions between organic molecules and biological targets.Â Research Interests: Â Multicomponent reactions (MCRs),Â Chemical Inhibition of Bacterial Cell Division.